| Actor | Main Character | Seasons |
| Bella Shepard | Genesis Lythe | |
| Brit Marling | USS Athena Computer (voice) | |
| George Hawkins | Darem Reymi | |
| Gina Yashere | Lura Thok | |
| Holly Hunter | Nahla Ake | |
| Karim Diané | Jay-Den Kraag | |
| Kerrice Brooks | SAM | |
| Robert Picardo | The Doctor / Emergency Medical Hologram | |
| Sandro Rosta | Caleb Mir | |
| Stephen Colbert | Digital Dean of Students (voice) | |
| Tig Notaro | Jett Reno | |
| Zoë Steiner | Tarima Sadal |
| Actor | Character | |
| Alex Somerville | Furie Soldier | 1 |
| Alexa Yaphe | Quill | 1 |
| Alexander Eling | B'Avi | 3 |
| Angelica Lisk-Hann | Khionian Royal Guard | 1 |
| Anthony Natale | President Emerin Sadal | 1 |
| Arthur Ortiz | FNN Reporter (voice) | 1 |
| Ashley Poulin | Very small cadet | 1 |
| Atlas Blu Klamer | Scrap (voice) | 1 |
| Avaah Blackwell | Haile | 2 |
| Brian David Gilbert | DoT (voice) | 3 |
| Carla Deverish | Darem's Mother | 1 |
| Carlos Pinder | Kaira's Father | 1 |
| Cecilia Lee | Dzolo | 3 |
| Chiwetel Ejiofor | Maker (voice) | 2 |
| Chris Hong | Holo-guard | 1 |
| Chris Lightfoot | Darem's Father | 1 |
| Cirroc Lofton | (holographic recording) Jake Sisko | 1 |
| Dale Whibley | Kyle Djokovic | 2 |
| Dale Whibley | Kyle Jokovich | 2 |
| Daniel Fernandes | Med Tech | 1 |
| Daniela Sandiford | Music Instructor | 1 |
| Darius "Jackie Cox" Rose | Bartender | 1 |
| Darren Richardson | Torothan shuttle computer (voice) | 1 |
| David Benjamin Tomlinson | Starfleet officer | 1 |
| David Keeley | Obel Wochak | 1 |
| Diedrie Henry | Museum Display Computer (voice) | 1 |
| Dillon Jagersky | Khionian Royal Guard | 1 |
| Dorothy Atabong | L'vanna | 1 |
| Graham Nox | Cadet Oren (voice) | 1 |
| Ian Busher | Torothan senior guard | 1 |
| itchie Lawrence | Darem's posse member | 1 |
| Jaelynn Thora Brooks | Kaira | 1 |
| Jamie Groote | the Diva | 1 |
| Jeff Teravainen | Tomov | 1 |
| Jeremy Culhane | DoT (voice) | 3 |
| John Fray | Botany instructor | 1 |
| Joseph Chiu | Ensign Weldu | 2 |
| Joseph Messina | Cdt. Holloway | 1 |
| Joseph Messina | Cadet Holloway | 1 |
| Julian Young | Club Leader | 1 |
| Kaleb Tekeste | Furie Soldier | 1 |
| Katie Nora Ready-Walters | Terrified cadet | 1 |
| Kelly Fanson | Kaira's Mother | 1 |
| Ken Barnett | Lieutenant Hayden Thriss | 2 |
| Kenzyn Hoffman | Little Suliban | 1 |
| Kether Donohue | Almond Basket (voice) | 1 |
| Kieron River | Cadet | 1 |
| Kostyn Mitruk | "Mugato" | 1 |
| Layina Chand | Cdt. Kohli | 1 |
| Lily Du | Vitus Reflux (voice) | 1 |
| Lindsey Haun | Belle | 1 |
| Luciano Fernandez | Young Caleb Mir | 1 |
| Lynn Anne Zager | Detention center computer (voice) | 1 |
| Marcia Adolphe | Interpreter | 1 |
| Martin Roach | Doctor kol | 1 |
| Mary Wiseman | Sylvia Tilly | 1 |
| Mia Yaguchi-Chow | Darem's posse member | 3 |
| Michael Brown | Lieutenant Thelonious Dandrid | 2 |
| Nicole Dickinson | Lieutenant Astrid Atlee | 2 |
| Paul Giamatti | Nus Braka | 2 |
| Piotr Michael | President Sadal's voice chip (voice) | 1 |
| Raffa Virago | Cadet Pickford | 3 |
| Raoul Bhaneja | Commander Kelrec | 4 |
| Rebecca Quin | Lieutenant Mackenzie Ya | 2 |
| Rekha Shankar | DoT (voice) | 3 |
| Ritchie Lawrence | Darem's posse member | 2 |
| Romeo Carere | Ocam Sadal | 5 |
| Scott Blachar | Sullivan | 1 |
| Scott Gemmel | Darem's posse member | 2 |
| Scott Gemmell | Darem's posse member | 1 |
| Scott Yamamura | Tinn Valaak | 1 |
| Sean Jones | Enok | 1 |
| Solen Morales | Little Orion | 1 |
| Sophia Wynter | Young SAM | 1 |
| Stephanie Komure | Miyazaki Ship Computer (voice) | 1 |
| Stephen Adekolu | N'Duwo Skra | 1 |
| Tabitha Tao | Holo-guide | 1 |
| Tatiana Maslany | Anisha Mir | 1 |
| Tawny Newsome | Illa Dax | 1 |
| Tremaine Nelson | Thar | 1 |
| Tricia Black | Lieutenant Rork | 1 |
| Troy James | Furie Soldier | 1 |
| Wendy Schaal | Charlene | 1 |
| Wyatt Lamoureux | Khionian Priest | 1 |
| © Graham & Ian Kennedy | Page views : 4,023 | Last updated : 3 Mar 2026 |