| •1 | Travis Mayweather visits his home ship, the ECS Horizon, for the first time since leaving to join Starfleet. He is saddened to learn of his father's recent death.1
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| •2 | A group of Borg which have been frozen on Earth's polar region since being destroyed by the Enterprise-E in 2063 are revived by a team which is investigating the debris. They assimilate the investigators and escape the planet, but are subsequently destroyed by the NX-012
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| •3 | A Xindi attack on Earth kills 7 million people, including Trip's sister Elisabeth. Enterprise is recalled and sent to the Delphic Expanse to investigate the origin of the Xindi weapon and prevent further attacks.3
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| •3 | T'Pol resigns from the Vulcan High Command to take part in Enterprise's mission to the Delphic Expanse.3
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| •4 | The Enterprise discovers the Vulcan ship Seleya adrift in the expanse, it's crew driven insane by the effects of Trellium-D. T'Pol also experiences the effects of the substance when she boards the ship4; she becomes a habitual user of it afterwards.5
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| •6 | The NX-01 discovers a Xindi outpost which is assisting in the construction of the weapon intended to destroy Earth. Archer manages to convince the leader of the facility to sabotage his next shipment.6
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| •7 | The NX-01 encounters a group of Humans who have lived on a planet in the Delphic Expanse for more than a centry after being abducted from Earth.7
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| •8 | When Trip is badly injured in an accident, Phlox creates a replica of him from a Lyssarian desevae in order to harvest neural tissue, in spite of the fact that the replica is a sentient being who will be killed by the procedure. The replica, named Sim, enjoys a brief romantic attraction to T'pol before his death.8
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| •9 | The prototype Xindi weapon fails a test firing thanks to the sabotage arranged by Captain Archer. Archer's attempt to steal the weapon fails, but he is able to acquire detailed scans of the device thanks to some help from Shran.9
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| •10 | The NX-01 discovers a sentient being adrift in a pod within a super-anomaly. This marks first contact with the Sphere Builders.10
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