The Xindi attack on Earth in 2152 resulted in over 7 million casualties, one of the most devastating single losses of life ever experienced. The NX-01 Enterprise was sent into the Delphic Expanse in order to locate the Xindi and attempt to end the conflict before further attacks could be mounted. 
After much effort, Captain Archer finally managed to track down the location of the main Xindi weapon at Azati Prime by means of an elaborate ruse involving the designer.  The ship reached the system to find an impenetrable defence net around the planet where the weapon was stationed; Archer took a captured Xindi shuttle down in an attempt to destroy the weapon, but the attempt failed and he was captured. The Xindi Reptilians subjected the Enterprise to a devastating attack, virtually destroying the ship before Archer managed to convince the ruling Xindi council to cancel the attack. 
Subsequently the ship managed to become operational again, largely by means of a stolen warp coil.